Aberdeen scientist’s show link between deficiency of sunlight, vitamin D and autoimmune diseases

Pharmiweb have reported that scientists at the University of Abeerdeen have demonstrated for the first time a clear link between sunlight, vitamin D and an impact on regulatory cells in the immune system in findings that might provide new insights into diseases such as multiple sclerosis.

Some studies have suggested a link between vitamin D deficiency and autoimmune diseases such as MS. This possible link might also explain the increasing prevalence of autoimmune disease among those living far from the equator, where there are lower levels of winter sun

University of Aberdeen researchers studied patients in the north of Scotland – which has the highest rate of MS in the UK – who were being treated during winter with artificial UV-B light therapy for skin diseases caused by their immune systems acting inappropriately

Dr Anthony Ormerod, Clinical Reader in Dermatology at the University, said: “Our study shows that UV-B light, which mimics sunshine, can have a striking effect on the immune system of patients.

“We found that UV-B light boosted the production of vitamin D, and of regulatory T cells, which play an important role keeping our immune systems in check..While too much exposure to sunlight is harmful and increases skin cancer risk, these results suggest that subjects in our study would have some benefits from small amounts equivalent to summer exposure in the winter but more work needs to determine the role of sunlight and the role of supplementing the diet with vitamin D.”

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Product Evaluation Engineer – South Wales

Hannah Milward at CK Science is recruiting a Product Evaluation Engineer to join a leading medical device organisation at their site in South Wales on a temporary basis for the duration of 9 months

The Job:

The main purpose of the Product Evaluation Engineer will be to improve the success of New Product Developments (NPD). The Product Evaluation Engineer has responsibility for the generation of documentation and conduct of testing to support the Product Evaluation Engineer activities within NPD projects. The Product Evaluation Engineer shall ensure that valid and robust data is obtained and documented during execution of validation and verification activities.

 

Responsibilities:

The main responsibilities of this Product Evaluation Engineer position will be to:

  • Produce design verification protocols, reports and perform the product testing where necessary
  • Design, develop and validate appropriate test method
  • Participate in NPD phase reviews, presenting the results and progress summaries of activities for which they are responsible
  • Ensure clinical model definition – translation of the intended clinical usage of a device into a definition in quantifiable engineering terms of the operational and environmental conditions that the device must withstand
  • Participate in risk management and FMEA exercises
  • Review and contribute to the necessary design input documents
  • Interface with design, marketing, clinical, manufacturing and quality teams to ensure the product evaluation function is fully integrated within the NPD team
  • Conduct programmes for extended life / reliability testing of new products
  • Analyse and report on Customer Enquiries
  • All other essential related duties as required

Qualifications and skills:

As a Product Evaluation Engineer, you will have the following qualifications, skills and experience:

  • Graduate or equivalent calibre in science, engineering or technology discipline with demonstrable relevant experience, preferably within the medical device industry
  • Experience of quality or product test fields
  • Good organisational skills
  • Attention to detail
  • Concern for quality and standards
  • Customer focus
  • Written communication skillsHannah Milward - Recruiter at CK Science

How to apply:

Apply online:

For more information or to apply for the Product Evaluation Engineer position please contact Hannah Milward on 0114 2839956 or email hmilward@ckscience.co.uk. Please quote reference SH24715 in all correspondence.

 

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Olympic Team GB work with scientists on gene tests for injuries

As reported by the BBC, Scientists behind Olympic Team GB are working on genetic tests to understand why some athletes are prone to injury Scientists at the Institute for Human Health and Performance at University College London are currently researching how and why tendon injuries and stress fractures occur as they are common in elite athletes University College London’s Prof Hugh Montgomery says they have found a gene they think strongly influences the risk of stress fracture…….If we understood that genetic component we would have a much better understanding of the patho-physiology – the disease processes that let that happen” The study has been working with the English Institute of Sport (EIS), which aims to apply the latest in sports science and medicine for the benefit of Britain’s Olympic and Paralympic athletes. EIS’s Director of Sport Science, Dr Ken van Someren said “If we can identify some particular genes that are associated with a higher risk of injury in certain individuals, and we think we’re close, we can tailor the training, conditioning and preparation that we put those individuals through.”

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Science jobs in the Republic of Ireland

Here are a few a of our latest science jobs in the Republic of  Ireland:

Senior Manufacturing Engineer, County Limerick

Automation Engineer, Med. Devices, County Limerick

Quality Engineer – County Limerick, Ireland

Senior Quality Engineer – County Limerick, Ireland

 

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GSK supports Olympics anti doping operation

The Guardian has reported that GSK today marks its role as Official Laboratory Services Provider for the London 2012 Olympic and Paralympic Games by launching its first UK advertising campaign to celebrate the role that anti-doping science will play in helping ensure this summer’s Games are the cleanest possible.

The multimillion-pound ad campaign features a string of British athletes, including Marlon Devonish and Phillips Idowu to highlight its role running the anti-doping testing laboratory for the London Olympic games.

The London 2012 anti-doping laboratory, provided by GSK in partnership with the London Organising Committee for the Olympic and Paralympic Games (LOCOG) and King’s College London opened today and will be operational 24 hours a day, seven days a week. More tests will be carried out at the London 2012 lab, based at GSK’s Harlow site, than at any other Games with every medallist and up to 50 per cent of all competing athletes being tested.

 

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200 life sciences jobs created

As reported by BBC News, a £12.5m upgrade of Dundee University’s College of Life Sciences could create 200 life sciences jobs.

The new scientific research jobs will be created at the University’s Centre for Translational and Interdisciplinary Research (CTIR). Work on the upgrade is due to be complete in the autumn of next year.

The 200 research staff will be joining an already established scientific community at the University. The college currently has over 1,000 scientists, research students and support staff from 62 countries across the world working there.

As explained, by Professor Michael Ferguson, dean of research in the College of Life Sciences, the new facility will bring together scientists from a range of disciplines including “…mathematical biology and biophysics, bioinformatics, data analysis and software development.” It is hoped that this will inspire innovation which will then go on to develop novel drugs and medicines of the future.

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Lead Supplier Quality Engineer – Kent

Jason Johal at CK Science is currently recruiting for a Supplier Quality Lead Engineer to join a global Healthcare company based in Kent

Responsibilities:

As Supplier Quality Lead Engineer you will:

  • Be responsible for driving exceptional product quality for the patient, customer value beyond expectations, regulatory assurance and optimized Cost of Quality
  • Lead, manage and implement supplier/engineering changes, New Product Introductions, and transfers
  • Interface with Suppliers, Engineering, Service, Manufacturing and Sourcing to drive Quality improvements
  • Assure Corrective and Preventive Action plans are developed and executed at assigned suppliers in compliance with CAPA process
  • Manage the Quality Management System
  • Be involved with internal and supplier audits
  • Complete all planned Quality & Compliance training within the defined deadlines
  • Ensure a compliant and qualified supply base by conducting supplier evaluations

Qualifications:

The successful Supplier Quality Lead Engineer will have the following qualifications, skills & experiences:

  • Aware of and ensure compliance with the Quality Manual
  • Quality Management Systems
  • Quality Management Policy
  • Bachelors Degree in an engineering or technical discipline (or non-technical degree with extensive experience in manufacturing, engineering or quality assurance experience, or an Associate’s Degree with extensive manufacturing, engineering or quality assurance experience)
  • Experience in manufacturing, engineering design, quality assurance or regulatory assurance
  • ASQ Certified Quality Engineer (desirable)
  • Demonstrated knowledge of Quality Management System tools, continuous improvement methodologies & in-depth understanding of site level products & related processes.
  • Demonstrated expertise to effectively communicate within all levels of the organization around concepts of design controls, design verification and validation activities; production and process controls; Corrective & Preventive Action (CAPA), complaints & risk management; & product quality improvement using tools such as six sigma, DFR, etc.

The company:

The successful candidate for this Supplier Quality Lead Engineer job will be join a leading global healthcare company that provides products and services used as tools for biopharmaceutical manufacturing, drug discovery and the latest in cellular technologies. In return there are challenging career opportunities, professional training and competitive compensation.

Jason Johal - Manager at CK ScienceHow to apply:

Apply online:

To apply for this Supplier Quality Lead Engineer position, contact Jason Johal via email jjohal@ckscience.co.uk or telephone 01438 723 500.  Please quote reference ST24693 in all correspondence.

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Wood Group PSN create 150 Aberdeen jobs

The BBC has reported that the energy company Wood Group is creating 150 jobs at its Production Services Network (PSN) division in Aberdeen.

The company is setting up a dedicated project delivery arm to the business, which they hope will help it secure and deliver large-scale North Sea projects.

Earlier this year, it was awarded a £250m contract from Premier Oil to deliver services to the Balmoral support vessel, which provides services for six oil fields.  WGPSN has taken on more than 1,000 new employees in the UK this year and currently Its UK-based onshore and offshore workforce now stands at more than 8,300.

WGPSN estimates the oil and gas project market worldwide to be worth nearly £100bn a year – of which about 30% involves brownfield projects.

 

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Bristol-Myers Squibb and AstraZeneca strengthens diabetes alliance

WorldPharmaNews reported that Bristol-Myers Squibb company announced today that they will acquire biopharmaceutical company Amylin Pharmaceuticals Inc.

Following BMS’s acquisition of Amylin, BMS and Astra Zeneca will enter into collaboration arrangements, based on the framework of the existing diabetes alliance, regarding the development and commercialisation of Amylin’s portfolio of products.

AstraZeneca will make a payment to Amylin, as a wholly owned subsidiary of Bristol-Myers Squibb, in the amount of approximately $3.4 billion in cash. Profits and losses arising from the collaboration will be shared equally.

Lamberto Andreotti, chief executive officer, Bristol-Myers Squibb said “The acquisition of Amylin by Bristol-Myers Squibb is also a unique way for Bristol-Myers Squibb and AstraZeneca to expand the alliance between the two companies, and it demonstrates Bristol-Myers Squibb’s innovative and targeted approach to partnerships and business development.

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MCerts level 2 Environmental Consultant – Dublin

Barney Smith at CK Science is recruiting for a MCerts level 2 qualified Environmental Consultant for an Environmental Testing and Monitoring company in Dublin on a permanent basis.

Responsibilities:

As an Environmental Consultant you will be responsible for air monitoring and stack emissions testing on a number of different sites based around the Dublin area.

Qualifications:

The successful candidate for this Environmental Consultant role must be qualified to minimum MCerts level 2 and have completed parts 1-4 within the course.

The company:

The company operate across the UK and Ireland, as a dedicated stack emissions testing contractor, providing independent advice and support to manufacturing and process sites in compliance with environmental legislation.

Barney Smith - Manager at CK ScienceHow to apply:

Apply online:

For more information or to apply for this MCerts level 2 Environmental Consultant position please contact Barney Smith on 0191 384 8905 or email bsmith@ckscience.co.uk. Please quote reference DH24652 in all correspondence.

 

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Aesica creates 100 jobs on Sheppey

Kent Online have reported that Aesica the pharmaceutical company is creating up to 100 jobs on the Isle of Sheppey.

Aesica is creating the jobs at its Queenborough plant over the next three years as the site is prepared for major expansion. The latest development follows the opening last year of a £3m Potent Manufacturing Facility.  Aesica will be looking for candidates with a manufacturing background who are keen to pursue a career or apprenticeship in the pharmaceutical industry.

Simon Clough, managing director of Aesica Formulated Products, said: “This is an exciting time for Aesica and the local community. Not only are we growing as a business, we’re also creating up to 100 new jobs which is a fantastic boost for the region’s economy.

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P&G help London clean up for the Olympics!

SuperSavyMe has reported that P&G has teamed up with the Mayor of London to bring the P&G Capital Clean Up campaign to help clean the capital before the London 2012 Olympic Games

The campaign started in March 2012 and over the last three months, Proctor and Gamble have hosted  a series of clean up events designed to bring Londoners together to spruce up neglected areas of the city as London gears up to host the Olympic games.

The events so far have involved clearing the region of 1,000 bags of litter, removing unsightly graffiti, and restoring swathes of habitat. The public can get involved by signing up to participate in one of the organised clean up events at www.pgcapitalcleanup.com

P&G are official sponsors of the London Olympic Games.

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Research says that men who drink 7 cups of tea a day are 50% more likely to develop prostate cancer

The Telegraph reported that a research study at Glasgow University  has said that men who drink a lot of tea a day are 50 per cent more likely to develop prostate cancer

Glasgow University found that people who drink more than seven cups of tea are at a much higher risk of getting the disease than those who consume three cups or fewer.

The warning comes after scientists at the University of Glasgow tracked the health of more than 6,000 men for four decades.  The participients were aged between  21 and 75 were asked to complete a questionnaire about their usual consumption of tea, coffee and alcohol as well as their smoking habits and general health, and had to attend a screening examination.

Dr Kate Holmes, head of research at The Prostate Cancer Charity, said: ‘Whilst it does appear that those who drank seven or more cups of tea each day had an increased risk of developing prostate cancer, this did not take into consideration family history or any other dietary elements other than tea, coffee and alcohol intake……It is therefore unclear as to whether there were other factors in play which may have had a greater impact on risk.

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Merck sign $303 million biotherapeutics deal

PharmaTimes has reported that Merck & Co has entered into a possible $303 million USD collaboration with Ambrx to develop ‘smart bomb’ antibodies.

Merck hope to develop biologic drug conjugates using Ambrx’s “site-specific protein medicinal chemistry technology”

Merck is paying an upfront fee of $15 million and is eligible to receive milestones totalling up to $288 million. Ambrx will also receive royalties.

Richard Murray, head of biologics and vaccines research at Merck said that this collaboration will allow us to combine Ambrx’s expertise in site-specific protein conjugation chemistry with Merck’s expanding antibody capabilities and extensive small molecule resources.

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UK manufacturing to get £6.5m through R&D projects

The Engineer has reported that UK manufacturing is to receive a £6.5m innovation boost through 16 new research and development projects to develop new production technologies

The Engineering and Physical Sciences Research Council and the Technology Strategy Board are to provide grant funding to support the development of new technologies that have the potential to underpin new production processes in a wide range of industrial applications and market sectors. The research will focus on novel manufacturing processes and techniques, resource efficiency and greater environmental sustainability through the efficient disposal or recycling of asset.

Companies including Airbus Operations, GKN Aerospace and Unilever will lead the projects, which will lead to technologies such as innovative car-painting methods, autonomous intelligent machining, the online control of welding processes using ultrasonic test techniques, and sustainable and resource-efficient titanium cutting.

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Welsh Water invest £1bn in renewable energy projects

The Guardian has reported that Welsh Water  has announced it will be spending £1billion on infrastructure projects in Herefordshire, Wales and Deeside over the next three years.

Welsh Water which is owned by not for profit Glas Cymru is upgrading its treatment works, rebuilding 22 of them, maintaining its networks of water mains and sewers and importantly investing more money into renewable energy projects.

The company, which has 2,000 employees, says its investment means jobs for a further 1,500 people.

The chairman of Welsh Water Bob Ayling said: “Our ambition is to deliver the best possible outcomes for our customers supplying drinking water of the highest quality and safeguarding the environment that we look after on behalf of the communities we serve.

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Two Scientists Win Largest Technology Award

As reported by the BBC News, two scientists have been awarded the Millenium Technology Prize for their scientific contributions to improving the quality of human life and in encouraging sustainable development.

Two Scientists Win Largest Technology Award in the WorldAwarded once every two years, the Millenium Technology Prize is the largest technology prize in the world. This is the first time the prize has been awarded to two scientists, Dr Shinya Yamanaka and Linus Torvalds. The two winners split the 1.2m euros prize.

Dr Shinya Yamanaka

Dr Shinya Yamanaka is a stem cell scientist who discovered how to program human cells to mimic embryonic stem cells. These cells can become any cell in the body. This is called induced pluripotent stem (iPS) cells. The scientists discovery will now contribute to the development of regenerative medicine.

Linus Torvalds

Linus Torvalds created a new open source operating system for computers.

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UK offshore wind could create 215,000 Jobs

The Bloomsberg Business week reported that the U.K. offshore wind industry could create 215,000 jobs and boost exports by up to 22.5 billion pounds by 2030.

The Centre for Economics and Business Research said in a report commissioned by Irish wind developer Mainstream Renewable Power Ltd that the Development of the industry may “see an annual 1 percent uplift” in gross domestic product.  The estimates are based on the installation of 49 gigawatts of offshore wind by 2030 resulting in 97,000 jobs created by 2020, assuming offshore wind generation reaches 17 gigawatts.

Mainstream Renewable’s Chief Executive Officer Eddie O’Connor said “By creating a new industry, offshore wind will create jobs, assist in balancing the trade deficit and boost GDP at a time of economic uncertainty,”

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Scientists have grown human bone from stem cells

The Telegraph has reported that scientists have succeeded in growing human bone from stem cells in a laboratory, which they claim may eventually pave the way for patients to have broken bones repaired or replaced with new ones grown outside the body.

The researchers started with stem cells taken from fat tissue. It took around a month to grow them into sections of fully-formed living human bone up to a couple of inches long.  The technology, which has been developed along with researchers at the Technion Institute of Research in Israel, uses three dimensional scans of the damaged bone to build a gel-like scaffold that matches the shape.

The first trial in patients is on course to be conducted later this year, by an Israeli biotechnology company Bonus BioGroup that has been working with academics on the technology.

Professor Avinoam Kadouri, head of the scientific advisory board for Bonus BioGroup, said: “There is a need for artificial bones for injuries and in operations…..We use three dimensional structures to fabricate the bone in the right shape and geometry. We can grow these bones outside the body and then transplant it to the patient at the right time”

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Norwegian oil services firm Aker Solutions to create 1300 new jobs in London

The Telegraph reported that Norwegian oil services firm Aker Solutions says it aims to build up a 1 700-strong London engineering hub thereby creating 1 300 new jobs by 2015, as growth in global oil and gas markets drives demand for the company’s technologies and services.

Aker Solutions provides oilfield products, systems and services for customers in the oil and gas industry, and is listed on the Oslo stock exchange. The company, which employs more than 3000 people in the UK, opened a new office in Chiswick Park, West London, last year.

UK Prime Minister David Cameron said: “Aker Solution’s decision to create 1300 new jobs at a new engineering hub in Chiswick is great news for the local economy and it is a vote of confidence in the skill, expertise and professionalism of our engineering sector.”

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